After more than 25 years of industrial experience in the pharmaceutical industry, Dr. Pottorf felt the calling to “pay back” for his education in chemistry.  His experience in Drug Discovery involved medicinal chemistry studies in cardiovascular, CNS, anti-inflammatory and cancer therapeutic areas.  He was involved in the discovery of an antihypertensive drug, Cozaar, and similar compounds.  Additionally, he was involved in the discovery of preclinical compounds to treat pulmonary arterial hypertension and as anti-tumor agents.  Dr. Pottorf is a co-author on more than 30 peer-reviewed scientific articles and co-inventor on several issued patents.

Dr. Pottorf and his wife reside in Indianapolis and have three grown sons, Brad, Ryan and Andrew.  They also recently welcomed their first grandchild, Arabella, to their family.

Dr. Pottorf has served at Anderson University since 2015.

B. A. Chemistry, University of Northern Colorado
Ph.D. Biochemistry, Indiana University
Postdoctoral Fellow, University of Wisconsin-Madison

Recent publications:

Wagner, J.; Kline, C. L.; Pottorf, R. S.; Nallaganchu, B. R.; Olson, G. L.; Dicker, D. T.; Allen, J. E.; El-Deiry, W. S.; The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity. Oncotarget20145, 12728-12737.

Ekins, S.; Pottorf, R.; Reynolds, R. C.; Williams, A. J.; Clark, A. M.; Freundlich, J. S.; Looking back to the future: Predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis. J. Chem. Inf. Model.; 201454, 1070-1082.

Zhu, J., Pottorf, R. S.; Player, M. R.; Solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides. Tetrahedron Lett200647, 7267-7270.

Pottorf, R. S.; Player, M. R.; Process technologies for purity enhancement of large discovery libraries.  Curr. Opin. Drug Disc. & Develop. 2004, 7, 777-783.

Vergnon, A. L.; Pottorf, R. S.; Winters, M. P.; Player, M. R.; Solid-phase synthesis of a 4-substituted g-lactam library. J. Comb. Chem. 2004, 6, 903-910.

Recent patents:

Stogniew, M.; Allen, J. E.; Pottorf, R. S.; Nallaganchu, B. R.; Olson, G.; 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-A]pyrido[4,-3-D]pyrimidin-5(3H)-one, salts thereof and methods of using the same in combination therapy. US 9,265,765 (Issued Feb. 23, 2016).

Tomczuk, B. E.; Olson, G. L.; Pottorf, R. S.; Wang, J.; Nallaganchu, B. R.; Zhang, Y.; Arginase inhibitors and methods of use thereof. US 8,894,970. (Issued Nov. 25, 2014).

Schuster, V. L.; Chi, Y.; Wasmuth, A. S.; Pottorf, R. S.; Olson, G. L.; Prostaglandin transporter inhibitors and uses thereof.  US 8,952,150. (Issued Feb. 10, 2015).